Homology Modeling and Protein Structure Analysis: From Sequence to Structure-OnlineWorkshop

About the Workshop

This intensive workshop introduces participants to the complete pipeline of homology modeling, from sequence analysis to 3D structure prediction and validation. Through guided tutorials and hands-on exercises, learners will gain experience in using bioinformatics tools and databases to analyze protein structures and derive meaningful biological insights.

What You Will Learn

• Fundamentals of protein structure (primary to quaternary levels)

• Principles and applications of homology modeling

• Sequence alignment and template selection

• 3D structure prediction using bioinformatics tools

• Model validation techniques (Ramachandran plot, ProSA)

• Structural analysis and visualization

• Identification of active sites and binding pockets
  

Course Features

• Live online sessions

• Interaction with expert resource persons

• Access to modeling tools and databases

• Lecture PPTs and session recordings

• e-Certificate upon completion
  

Learning Outcomes

• Perform homology modeling of protein structures

• Validate and refine predicted models

• Analyze structural features and functional sites

• Use bioinformatics tools for protein structure studies

• Apply structural insights in research and drug discovery
  

Who Can Join

• Undergraduate and postgraduate students in Life Sciences

• Research scholars and faculty members

• Professionals from Biotechnology, Biochemistry, Microbiology, and related fields

• Medical, Pharmacy, and Chemical Sciences background participants

Course Fee
 Indian Participants: ₹799 INR
 International Participants: $55 USD

Workshop Module

Module 1: Foundations of Protein Structure and Homology Modeling

• Overview of protein structures (primary → quaternary levels)

• Concept & applications of homology modeling

• Steps in homology modeling (alignment → model building → refinement)

• Template selection: sequence identity and structure quality

• Key databases & tools: PDB, UniProt, BLAST
  

Module 2: Building and Validating a Homology Model

• Hands-on practice using SWISS-MODEL and Phyre2

• Model validation with Ramachandran Plot and ProSA

• Troubleshooting and optimization tips
  

Module 3: Structural Analysis and Applications

• Identifying active sites and functional domains

• Binding pocket and ligand site detection

• Visualization and comparative structural analysis using PyMOL, CastP, IntePRO, JPred, and PSIPRED

21–23 April 2026 | 6:30 PM IST | Online | Certificate